PRESIDENTIAL ADDRESS1

Selectivity—Key to Chemotherapy: Presidential Address1

For many years, chemotherapists have sought the touchstone which would turn lead into gold, the magic bullet of Ehrlich which would go directly to the target without harming normal cells. There have been many approaches to this goal, but in essence there have been two main philosophies. One is that you should find the basic biochemical differences between the target and the host, whether the ta...

Therapeutic Attack of Hypoxie Cells of Solid Tumors: Presidential Address1

Hypoxie cells of solid tumors are relatively resistant to therapeutic assault. Studies have demonstrated that oxygen-deficient tumor cells exist in an environment conducive to reductive reactions making hypoxic cells particularly sensitive to bioreductive alkylating agents. Mitomycin C, the prototype bioreductive alkylating agent available for clinical use, is capable of preferentially killing ...

Ultraviolet Radiation and Immunology: Something New under the Sun Presidential Address1

The carcinogenic activity of solar radiation has been known for nearly a century. However, within the past few years, we have realized that exposing the skin to sunlight also has profound immunological effects on the host and that these immunological changes can contribute to the development ofskin cancer and alter host resistance to infectious diseases. These findings have led to the developme...

Prevention—Therapy—Basic Science and the Resolution of the Cancer Problem: Presidential Address1

Endogenous Carcinogenesis: Molecular Oncology into the Twenty-first Century- Presidential Address1

In this paper I will consider an aspect of carcinogenesis that needs further in-depth study because it could be a major cause of human cancers. I am referring to the Damoclean possibility that certain normal endogenous cellular processes are inher ently mutagenic and that this intrinsic mutagenesis is a signif icant factor in the etiology and pathogenesis of some human cancers. Moreover, I will...